Structure of PDB 8bhf Chain W1 Binding Site BS02

Receptor Information

>8bhf Chain W1 (length=86) Species: 9986 (Oryctolagus cuniculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>8bhf Chain C2 (length=151)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaac
gcacuugcggccccggguuccucccggggcuacgccugucugagcgucgc
u

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>........>>>..>...>>>....
<<<..>>><<<<<<<<.......>>>>>>>>...................
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bhf Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R20 R21 C22 G23 Y39 K42 T59 G62 R63 M64 R65 H66 L67 V70 Y71 R72 F74 R75 H76 R79 T82 T83 P84 K85 K87
• Binding residue (residue number reindexed from 1): R19 R20 C21 G22 Y38 K41 T58 G61 R62 M63 R64 H65 L66 V69 Y70 R71 F73 R74 H75 R78 T81 T82 P83 K84 K86

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:8bhf, PDBe:8bhf, PDBj:8bhf
• PDBsum: 8bhf
• PubMed: 37653241
• UniProt: U3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)