Structure of PDB 7qh7 Chain W Binding Site BS02

Receptor Information

>7qh7 Chain W (length=100) Species: 9606 (Homo sapiens)

RRQGIKKMEGHYVHAGNIIATQRHFRWHPGAHVGVGKNKCLYALEEGIVR
YTKEVYVPHPRNTEAVDLITRLPKGAVLYKTFVHVVPAKPEGTFKLVAML

Ligand information

>7qh7 Chain A (length=1256)

gcuaaaccuagccccaaacccccaccuuacuaccacaacuuagccaaacc
auuuacauaaaguauaggcgauagaaauugauggcgcaauagauauagua
ccgcaagggaaagacaagcauaauauagcaaggacuaaccccuauaccuu
cugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaa
gacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacaccc
gucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuagucca
aagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaa
aaaaugaucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucauauagaagaacuaauguuaguauaaguaacaugaaaacauucuc
cuccgcauaagccugcgucagaucugacaauuaacagcccaauaucuaca
aucaaccaacaaguuauuacccucacugucaacccaaccaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
uccuuaaauaggcuccacgaggguucagcugucucuuacuuuuaaccagu
gaaauugaccugcccgugaggcgggcauaacacagcaagacgaagacccu
auggagcuuuaauuuauuaaugcaaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgaggcuaagacuucaccaguca
aagcgaagauccaauaacuugaccaacggaacaaguuacccuagggcaau
ccuauucuagaguccauaucaacaauaggguuuacuggaucaggacaucc
cgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccu
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
auuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagc
gccuucuaaaugauaucaucucaacuuaauacccacacccacccaagaac
aggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>....>>.>>.............
<<....>>........>>>...........<<<.......>>>...<.<<
......>>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>
>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<
..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<
<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...
<.....................>...>>>>>>........>>>>>>...<
<<<<...>>>>>.........>>>>>><......<<..<<<....>>><<
<<..<<<<........<<<<<..>>>>>......<<<...<<<<......
..............>>>>.......>>>.....<<.....>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>.......
.<<<.....>>>.....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>
.....>.....<<<<<.....>>>>>.......<<..<<<.<<...<<<<
<.<<<<<<..<<<<..<<<<<<<<.....>>>>>>>.>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>.<<<..<<<<.....>>>>.
.>>>.......<<<....>>>............>>>>..>>>>>>>...<
<<<<<<...<<.......>>...>>>>>>>.....<<<<..<<<<<..<<
.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>
.....>>>>......<<<<<<<....>>>.>>>>....>>..>>>.>>..
<<<.<<<.................>>>.>>><<<<<...<<<....>>>.
>>>>>.<<<................>>>............<<<<......
.>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh7 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R49 R50 K54 M56 E57 H59 A63 G64 N65 I66 R74 W75 K85 Y90 Y99 K101
• Binding residue (residue number reindexed from 1): R1 R2 K6 M8 E9 H11 A15 G16 N17 I18 R26 W27 K37 Y42 Y51 K53

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:7qh7, PDBe:7qh7, PDBj:7qh7
• PDBsum: 7qh7
• PubMed: 35177605
• UniProt: Q9P0M9|RM27_HUMAN Large ribosomal subunit protein bL27m (Gene Name=MRPL27)