Structure of PDB 6vep Chain W Binding Site BS02
Receptor Information
>6vep Chain W (length=296) Species:
9606
(Homo sapiens) [
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PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
Ligand information
>6vep Chain X (length=16) Species:
9606
(Homo sapiens) [
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TFEDYLHNVVFVPRPS
Receptor-Ligand Complex Structure
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PDB
6vep
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
R14 L37 F88 F89 Y91 F96 R118
Binding residue
(residue number reindexed from 1)
R11 L34 F85 F86 Y88 F93 R115
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6vep
,
PDBe:6vep
,
PDBj:6vep
PDBsum
6vep
PubMed
32483339
UniProt
P06213
|INSR_HUMAN Insulin receptor (Gene Name=INSR)
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