Structure of PDB 6ryr Chain W Binding Site BS02

Receptor Information
>6ryr Chain W (length=708) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTC
PALKGKVQKILIWKWGPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFR
NYQRKNDMDEPPSEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRIL
NHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELM
TVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMG
LGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVV
TYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYEL
ITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTP
LQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHM
LRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGN
QVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLL
LQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNM
RQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI
QAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRAAAA
AAAAAAAA
Ligand information
>6ryr Chain J (length=149) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcctatcgatgtatatatctgacacgtgcctggagactagggagtaatcc
ccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtg
ctagagctgtctacgaccaattgagcggcctcggcaccgggattctgat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ryr Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		M570 R836 R877 K879 S883 K884 W1148 R1183 K1191
Binding residue
(residue number reindexed from 1)		M98 R332 R373 K375 S379 K380 W644 R679 K687
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:6ryr, PDBe:6ryr, PDBj:6ryr
PDBsum6ryr
PubMed32543371
UniProtQ14839|CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (Gene Name=CHD4)

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