Structure of PDB 6icz Chain W Binding Site BS02

Receptor Information
>6icz Chain W (length=508) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFET
GQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEIT
AKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMP
PEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG
ERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF
TNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLS
PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM
SYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCG
WDGLIKLW
Ligand information
>6icz Chain G (length=84) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccuccgaacgguaagagccuagcauguagaacugguuaccuccagggu
uuccuugaugaugucauacuuauccuguccacag
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Receptor-Ligand Complex Structure
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PDB6icz Structures of the human spliceosomes before and after release of the ligated exon.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		W475 K500 K538 K541 K547
Binding residue
(residue number reindexed from 1)		W405 K430 K468 K471 K477
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1990403 embryonic brain development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6icz, PDBe:6icz, PDBj:6icz
PDBsum6icz
PubMed30728453
UniProtO60508|PRP17_HUMAN Pre-mRNA-processing factor 17 (Gene Name=CDC40)

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