Structure of PDB 6ezm Chain W Binding Site BS02

Receptor Information
>6ezm Chain W (length=212) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKAEQATQSQVINVHT
GIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEA
LGAVRGVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSC
EMIPHFLESFAEASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPN
GTNDVPSTKGVL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6ezm Chain G Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ezm Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H90 E94 H162
Binding residue
(residue number reindexed from 1)		H83 E87 H155
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ezm, PDBe:6ezm, PDBj:6ezm
PDBsum6ezm
PubMed29434040
UniProtP06633|HIS7_YEAST Imidazoleglycerol-phosphate dehydratase (Gene Name=HIS3)

[Back to BioLiP]