Structure of PDB 5me0 Chain W Binding Site BS02

Receptor Information
>5me0 Chain W (length=501) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAY
HVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIE
AIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFV
HVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPV
ATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGL
SGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANM
TEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITET
DATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAA
MSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVL
RDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFE
I
Ligand information
>5me0 Chain X (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucg
ucgguucaaauccggcccccgcaacca
..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>......
Receptor-Ligand Complex Structure
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PDB5me0 Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Resolution13.5 Å
Binding residue
(original residue number in PDB)
F804 K805 F809 I812 S844 R846
Binding residue
(residue number reindexed from 1)
F423 K424 F428 I431 S463 R465
Enzymatic activity
Catalytic site (original residue number in PDB) D401
Catalytic site (residue number reindexed from 1) D20
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0043024 ribosomal small subunit binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0009409 response to cold
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5me0, PDBe:5me0, PDBj:5me0
PDBsum5me0
PubMed27986852
UniProtP0A705|IF2_ECOLI Translation initiation factor IF-2 (Gene Name=infB)

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