Structure of PDB 8esz Chain V2 Binding Site BS02

Receptor Information
>8esz Chain V2 (length=214) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNLFVHRDTPEDNPNIPFEFTAENKKRVEAILSIYPEGHKRGAMIPLLDL
AQRQYGWLPISAMHKVAEILQLPNMRVYEVATFYTMFMRKPTGKYHIQVC
TTTPCWLRGSDDILETCKKQLGIGVGDTTKDRKFTISEVECLGACVNAPM
VAINDDYYEDLTSKDMQDILNDLKADKISPPGPRNGRFASEPKGEPTSLS
EEPKGPGFGLQAGL
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8esz Chain V2 Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8esz Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C128 T130 P132 C133 C169 L170 C173
Binding residue
(residue number reindexed from 1)		C100 T102 P104 C105 C141 L142 C145
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8esz, PDBe:8esz, PDBj:8esz
PDBsum8esz
PubMed36952377
UniProtQ9VX36

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