Structure of PDB 8rpy Chain V Binding Site BS02

Receptor Information

>8rpy Chain V (length=94) Species: 562 (Escherichia coli)

MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAIELDHDKVMNM
QAKAEFYSEVLTIVVDGKEIKVKAQDVQRHPYKPKLQHIDFVRA

Ligand information

>8rpy Chain B (length=120)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggcaa

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rpy Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
• Resolution: 2.64 Å
• Binding residue (original residue number in PDB): Q12 G13 K14 S17 R18 R19 R21 Y31 Q75 H88 D90
• Binding residue (residue number reindexed from 1): Q12 G13 K14 S17 R18 R19 R21 Y31 Q75 H88 D90

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0009314 response to radiation
• GO:0017148 negative regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rpy, PDBe:8rpy, PDBj:8rpy
• PDBsum: 8rpy
• PubMed: 38730238
• UniProt: P68919|RL25_ECOLI Large ribosomal subunit protein bL25 (Gene Name=rplY)