Structure of PDB 8iuh Chain V Binding Site BS02

Receptor Information
>8iuh Chain V (length=361) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTY
SRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSG
IRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQ
IVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTM
QLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLAN
VDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQ
SLVRSAFRDLLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTP
QEVRDFQRAQA
Ligand information
>8iuh Chain Y (length=81) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gctgccgaagcgagcacggtgctttccacaagatatataaagccaagaaa
tcgaaatactttcaagttacggtaagcatat
Receptor-Ligand Complex Structure
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PDB8iuh Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R67 G105 A108 R110 K113 R220 Y260 P261 R265 P359
Binding residue
(residue number reindexed from 1)		R62 G100 A103 R105 K108 R215 Y255 P256 R260 P313
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006359 regulation of transcription by RNA polymerase III
GO:0034599 cellular response to oxidative stress
GO:0070897 transcription preinitiation complex assembly
Cellular Component
GO:0000126 transcription factor TFIIIB complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuh, PDBe:8iuh, PDBj:8iuh
PDBsum8iuh
PubMed37165065
UniProtQ9HAW0|BRF2_HUMAN Transcription factor IIIB 50 kDa subunit (Gene Name=BRF2)

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