Structure of PDB 4bxs Chain V Binding Site BS02

Receptor Information
>4bxs Chain V (length=1262) Species: 8673 (Pseudonaja textilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AQLREYHIAAQLEDWDYNPQLTFKKIVYREYELDFKQEKPRDALSGLLGP
TLRGEVGDSLIIYFKNFATQPVSIHPQSAVYNKWSEGSSYSDGTSDVERL
DDAVPPGQSFKYVWNITAEIGPKKADPPCLTYAYYSHVNMVRDFNSGLIG
ALLICKEGSLNANGSQKFFNREYVLMFSVFDESKNWYRKPSLQYTINGFA
NGTLPDVQACAYDHISWHLIGMSSSPEIFSVHFNGQTLEQNHYKVSTINL
VGGASVTADMSVSRTGKWLISSLVAKHLQAGMYGYLNIKDCGNPDMKIKN
WEYFIAAEEITWDYAPEIPSSVDRRYKAQYLDNFSNFIGKKYKKAVFRQY
EDGNFTKPTYAIWPKERGILGPVIKAKVRDTVTIVFKNLASRPYSIYVHG
VSVSKDAEGAIYPSDPTHGKAVEPGQVYTYKWTVLDTDEPTVKDSECITK
LYHSAVDMTRDIASGLIGPLLVCKHKALSGVQNKADVEQHAVFAVFDENK
SWYLEDNIKKYCSNPSAVKKDDPKFYKSNVMYTLNGYASDRTEVLRFHQS
EVVQWHLTSVGTVDEIVPVHLSGHTFLSKGKHQDILNLFPMSGESATVTM
DNLGTWLLSSWGSCEMSNGMRLRFLDANYDDEDEGNEEEEEDDGDIFADI
FIPSEGNKRRYYIAAEEVLWDYSPKTTFKKAIFRSYLDDTFQTPSTGGEY
EKHLGILGPIIRAEVDDVIEIQFKNLASRPYSLHAHGLLYEKSSEGRSYD
DKSPELFKKDDAIMPNGTYTYVWQVPPRSGPTDNTEKCKSWAYYSGVNPE
KDIHSGLIGPILICQKGMIDKYNRTIDIREFVLFFMVFDEEKSWYFPCSL
HTFPAINGIPYQLQGLTMYKDENVHWHLLNMGGPKDIHVVNFHGQTFTEE
GREDNQLGVLPLLPGTFASIKMKPSKIGTWLLETEVGENQERGMQALFTV
IDKDCKLPMGLASGIIQDSQISASGHVGYWEPKLARLNNTGKYNAWSIIK
KEHEHPWIQIDLQRQVVITGIQTQGTVQLLQHSYTVEYFVTYSEDGQNWI
TFKGQMHFEGNSDGTTVKENHIDPPIIARYIRLHPTKFYNRPTFRIELLG
CEVEGCSVPLGMESGAIKNKEITASSYKKTWWSSWEPFLARLNLEGGTNA
WQPEVNNKDQWLQIDLQHLTKITSIITQGATSMTTSMYVKTFSIHYTDDN
STWKPYLDVRTSMEKVFTGNINSDGHVKHFFKPPILSRFIRIIPKTWNQY
IALRIELFGCEV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4bxs Chain V Residue 2430 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4bxs Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		K94 E109 D112 D113
Binding residue
(residue number reindexed from 1)		K83 E98 D101 D102
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016504 peptidase activator activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0010952 positive regulation of peptidase activity
GO:0035807 induction of blood coagulation in another organism
GO:0044469 envenomation resulting in positive regulation of blood coagulation in another organism
Cellular Component
GO:0005576 extracellular region
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4bxs, PDBe:4bxs, PDBj:4bxs
PDBsum4bxs
PubMed23869089
UniProtQ7SZN0|FA5V_PSETE Venom prothrombin activator pseutarin-C non-catalytic subunit

[Back to BioLiP]