Structure of PDB 7pf2 Chain U Binding Site BS02

Receptor Information
>7pf2 Chain U (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLK
SLVSKGTLVQTKGTGASGSFKLNKK
Ligand information
>7pf2 Chain J (length=339) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tacttacatgacaggatgtatatatctgacacgtgcctggagactaggga
gtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgttta
agcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggat
tctccaggcggccagtgcgcgatacttacatgacaggatgtatatatctg
acacgtgcctggagactagggagtaatccccttggcggttaaaacgcggg
ggacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaat
tgagcggcctcggcaccgggattctccaggcggccagtg
Receptor-Ligand Complex Structure
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PDB7pf2 Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution5.1 Å
Binding residue
(original residue number in PDB)		V39 G55 S57 K63 R78 K96 G97 G102 S103
Binding residue
(residue number reindexed from 1)		V5 G21 S23 K29 R44 K62 G63 G68 S69
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030261 chromosome condensation
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pf2, PDBe:7pf2, PDBj:7pf2
PDBsum7pf2
PubMed35581345
UniProtP10412|H14_HUMAN Histone H1.4 (Gene Name=H1-4)

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