Structure of PDB 6id0 Chain U Binding Site BS02

Receptor Information

>6id0 Chain U (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SGVENEDQQEVILVRTDQSGRVWPVNTKRQMVSTHEERERVRYFHDDDNL
SLNDLVKNEKMGTAENQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAER
ERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVY
LCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDK
GLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWS
MNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGK
EIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6id0 Chain U Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6id0 Structures of the human spliceosomes before and after release of the ligated exon.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	C675 Y677 C678 H718 H765
Binding residue (residue number reindexed from 1)	C128 Y130 C131 H171 H218
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0000398	mRNA splicing, via spliceosome

	Cellular Component
GO:0005654	nucleoplasm
GO:0071014	post-mRNA release spliceosomal complex

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Cellular Component

External links

PDB	RCSB:6id0, PDBe:6id0, PDBj:6id0
PDBsum	6id0
PubMed	30728453
UniProt	Q2TBE0\|C19L2_HUMAN CWF19-like protein 2 (Gene Name=CWF19L2)

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