Structure of PDB 5umd Chain U Binding Site BS02

Receptor Information
>5umd Chain U (length=180) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IDNSLNTNIHQYHIVGRAIPTAKDKNPNVYRMCIFAKNDTNAKSRFWYFM
KKINKLKKSNGELLACEQIKERFPLRVKNYGVLLRYDSRTGTHNMYKEFR
DTTKEGAIAQLYSEMAGRHRARASSINIIRISEISSSLVRRPHIKQLLKR
RLRFPALHLPTLQKEYRKKFASKRPSTYRM
Ligand information
>5umd Chain B (length=118) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacucguucauacuacaguggauacaccagaucccaucagaacucugaag
uuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaa
caccaggugaugagucag
<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>
>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>...
..>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R49 Y52 K55 K56 I57 K59 K61 S63 R93 R126 S128
Binding residue
(residue number reindexed from 1)		R45 Y48 K51 K52 I53 K55 K57 S59 R89 R122 S124
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum5umd
PubMed28288098
UniProtQ8IDS6

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