Structure of PDB 2xct Chain U Binding Site BS02

Receptor Information
>2xct Chain U (length=665) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKA
RLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIR
TLLLTFFYRFMRPLIEAGYVYIAQPPTKGLGEMNADQLWETTMNPEHRAL
LQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYNITSEMRESFLDYA
MSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGDVMG
KYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRFTEA
RMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIA
VGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILG
KSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEK
IAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTP
LQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKD
RAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEKQAQAIL
DMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDELTEI
RDRFGDDRRTEIQLG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xct Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		R1033 H1046 H1081 S1085 R1092 I1175 R1272
Binding residue
(residue number reindexed from 1)		R207 H220 H255 S259 R266 I349 R446
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:2xct, PDBe:2xct, PDBj:2xct
PDBsum2xct
PubMed20686482
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB);
Q99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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