Structure of PDB 8ir1 Chain T Binding Site BS02

Receptor Information
>8ir1 Chain T (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALKKPYGV
LYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDY
HVLDMIELGIENFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKS
LLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKRTPRIEL
EEMGPSLDLVLRRTHLASDDLYKLSMKMPKNISHDTFGTTYGRIHMQKQD
LSKLQ
Ligand information
>8ir1 Chain W (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8ir1 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K50 K57 N96 K97 K98
Binding residue
(residue number reindexed from 1)		K39 K46 N85 K86 K87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 maturation of LSU-rRNA
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ir1, PDBe:8ir1, PDBj:8ir1
PDBsum8ir1
PubMed37491604
UniProtQ9H7B2|RPF2_HUMAN Ribosome production factor 2 homolog (Gene Name=RPF2)

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