Structure of PDB 8imy Chain T Binding Site BS02

Receptor Information
>8imy Chain T (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPRDSLREELVITPLPSGDVAATFQFRTRWDSELQREGVSHYRLFPKALG
QLISKYSLRELHLSFTQGFWRTRYWGPPFLQAPSGAELWVWFQDTVTDVD
KSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYA
VLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRP
VCRNARCTSISWELRQTLSVVFDAFITGQGKKDWSLFRMFSRTLTEPCPL
ASESRVYVDITTYNQDNETLEVHPPPTTTYQDVILGTRKTYAIYDLLDTA
MINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYN
THPYRAFPVLLLDTVPWYLRLYVHTLTITSKGKENKPSYIHYQPAQDRLQ
PHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSAL
VPSMVAAKPVDWEESPLFNSLFPVSDGSNYFVRLYTEPLLVNLPTPDFSM
PYNVICLTCTVVAVCYGSFYNLLTRTFHIE
Ligand information
Ligand IDPA1
InChIInChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6+/m1/s1
InChIKeyMSWZFWKMSRAUBD-UKFBFLRUSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
CACTVS 3.341N[CH]1[CH](O)O[CH](CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)N)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)N)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1N)CO
FormulaC6 H13 N O5
Name2-amino-2-deoxy-alpha-D-glucopyranose;
alpah-D-glucosamine;
2-amino-2-deoxy-alpha-D-glucose;
2-amino-2-deoxy-D-glucose;
2-amino-2-deoxy-glucose
ChEMBLCHEMBL606759
DrugBank
ZINCZINC000003860469
PDB chain8imy Chain T Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8imy Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution3.22 Å
Binding residue
(original residue number in PDB)		D521 S523
Binding residue
(residue number reindexed from 1)		D497 S499
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0042765 GPI-anchor transamidase complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imy, PDBe:8imy, PDBj:8imy
PDBsum8imy
PubMed37684232
UniProtQ969N2|PIGT_HUMAN GPI transamidase component PIG-T (Gene Name=PIGT)

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