Structure of PDB 6az3 Chain T Binding Site BS02

Receptor Information
>6az3 Chain T (length=154) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQV
LAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEAN
AIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMS
EKKE
Ligand information
>6az3 Chain 2 (length=1078) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguauaucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgagcuucacuuaucgaau
gaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuu
ccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagac
aucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaa
cgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaac
acaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacu
gcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaa
ucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacu
gacagggaacgugagcuggguuuagaccgucgugagacagguugguuuua
cccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgug
cgagcgguggguguacgguacgcucacc
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.
....<<<<...........<.<<<..........>>>.>...........
.....................<<<<....>>>>..>>>>...>>>>>...
....>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<
<<....>>>.>>........<<<<<<..............<<<<......
.>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<
<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<
<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>......................<<.......>>.<.<>
.>.<.<<.....<<<...>>>..>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H25 K66 G68 R69 T79 K80 R82 W83 P84 R85 K86 R127 Y130 R131 G134 I136 T137 P138 Y139 M140 C141
Binding residue
(residue number reindexed from 1)		H24 K65 G67 R68 T78 K79 R81 W82 P83 R84 K85 R126 Y129 R130 G133 I135 T136 P137 Y138 M139 C140
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtA0A3S7WY02

[Back to BioLiP]