Structure of PDB 3jcs Chain T Binding Site BS02

Receptor Information

>3jcs Chain T (length=154) Species: 5661 (Leishmania donovani)

THYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQV
LAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEAN
AIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMS
EKKE

Ligand information

>3jcs Chain 2 (length=1119)

cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaauugccacucagaacu
gcuuacggcggggaauccaacuguauaauuaaaacauagguuugugaugc
auccaagugguguauaucgcaaacugauuucugcccagugcucugaaugu
caacgugacgagauucaccgacgcgcggguaaacggcgggagacucucuu
aagguagccaaaugccucgucuuccaauuagagacgcgcaugaauggauu
aaugagauucccucugucccgaguuacuaucuagcgaaacgacagucaag
ggaacggacuugaagggcuaagcggggaaagaagacccuguugaguuuga
cuccagucuggcucugugcggcgacaucugagguguaguauagguggaag
cgcaagcgcaaaugaaauaccaccacucggaaguugcuucacuuaucgaa
ugaagagaccaauggguuuagcguagucuggcuaugcaccgucuagguuu
gggaguaauuuuauggcggggugugcuugggcgugacucguggguaccca
accgugcuguaaacugaaccaacgggauugccucgugcaguuccgggucu
uguuucgagacaucugccagauggggaguuuggcugcggcuaucuguuac
acgacaacgcagguguccuaaggcgagcucagugggaacaaucucacgua
gaacacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucga
gacugcgaaagcaaggccagcgauccuuugcgaugaacaaaucauaccag
aggugucagaauaauuaccacagggauaacuggcuuguggcggccaagcg
auagcgacgucgcuuuuugauccuucgaugucggcucuuccuaaccuagc
gccgcagaagacgcuaaggguuggauuguucacccacugacagggaacgu
gagcuggguuuagaccgucgugagacagguugguuuuacccuacuuagcu
ggaaauugcgagaaaaaga

........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<.....<..>......>>>>><<.<<<<<<.<......>..>>>>>>.>>
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<
....<<<<......>>>>....>>..>>>>..>>>>>.............
......<...........<<<<<.......>>>>>.....>.....>>..
..>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<
........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<
<<<<.<<<<<<<...<<<.<<<<<<.<<<.....................
............................>>>.>>>>>>.>>>...<<<<<
.....<<<.....<<.....<<<<<<<...>>>>>>>....>>.....<.
..<..................<<<<<<..>>>>>>...............
..>..>................<<<<<<<<.......>>>>>>>>..>>>
...>>>>>.......>>>>>>>..>>>>>..<<<....>>><<<<<<...
........>>>>>>..<<...<<<<<<<...<<<<<<....>>>>>>...
..<<......>>....>>>>>>>...<<..<<<<<<.......>>>>>>.
>>.<<<....>>>.>>........<<<<<<..<<<.......>>>..>>>
>>>.........>>>>..>>>>>>.......<<.<...<.<.<.....<.
...>.....>.>.>....>.>.>.......<<<<<.<<<<<<..<<<<<<
<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>.
..>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>
...................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): H25 K66 I67 G68 R69 T79 K80 R82 W83 R85 K86 R127 Y130 R131 I136 T137 P138 Y139 M140
• Binding residue (residue number reindexed from 1): H24 K65 I66 G67 R68 T78 K79 R81 W82 R84 K85 R126 Y129 R130 I135 T136 P137 Y138 M139

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
• PDBsum: 3jcs
• PubMed: 27373148
• UniProt: A0A3S7WY02