Structure of PDB 3ccs Chain T Binding Site BS02

Receptor Information

>3ccs Chain T (length=119) Species: 2238 (Haloarcula marismortui) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEV
LRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTDGEEVPRPLDTSNVRVTD
LDLEDEKREARLESEDDSA

Ligand information

InChI=1S/Mg/q+2

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Mg

Name

MAGNESIUM ION

PDB chain

3ccs Chain T Residue 8057 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	3ccs Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.
Resolution	2.95 Å
Binding residue (original residue number in PDB)	L112 S114
Binding residue (residue number reindexed from 1)	L112 S114
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:3ccs, PDBe:3ccs, PDBj:3ccs
PDBsum	3ccs
PubMed	18455733
UniProt	P10972\|RL24_HALMA Large ribosomal subunit protein uL24 (Gene Name=rpl24)

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