Structure of PDB 1yhq Chain T Binding Site BS02

Receptor Information

>1yhq Chain T (length=119) Species: 2238 (Haloarcula marismortui)

SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEV
LRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTDGEEVPRPLDTSNVRVTD
LDLEDEKREARLESEDDSA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1yhq Chain T Residue 8057

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1yhq Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): L112 S114 D117
• Binding residue (residue number reindexed from 1): L112 S114 D117
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1yhq, PDBe:1yhq, PDBj:1yhq
• PDBsum: 1yhq
• PubMed: 15851032
• UniProt: P10972|RL24_HALMA Large ribosomal subunit protein uL24 (Gene Name=rpl24)