Structure of PDB 8vsa Chain SMPB Binding Site BS02

Receptor Information

>8vsa Chain SMPB (length=150) Species: 562 (Escherichia coli)

SATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRD
GEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYT
VVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR

Ligand information

>8vsa Chain TMRN (length=363)

ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccg
aggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacga
aaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuag
ccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucg
cguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguu
uguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacu
aagcauguaguaccgaggauguaggaauuucggacgcggguucaacuccc
gccagcuccacca

<<<<<<<.............<<<<<<<<.......<<..<<<..<<<<..
.....<<<................>>>.......................
.......<<<<<<<<<<.........>>>>.>>>>>><<<<<<.<<<<..
.....[.((((.....>>>>.....>>>>>>..........))))..].(
(((....(((...<<<<<)))....))))..........>>>>>......
<<<<....<<...((..(..>>....>>>>.............)..))..
..>>>>.....>>>..>>......>>>>>>>>.....<<<.......>>>
..>>>>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8vsa Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): E31 A32 G33 L34 A35 L36 V41 K42 R45 D53 Y55 V75 A76 L91 L92 N93 Q94 E96 E107 G108 Y109 T110 W122 C123 K124 K133 K134 Q135
• Binding residue (residue number reindexed from 1): E21 A22 G23 L24 A25 L26 V31 K32 R35 D43 Y45 V65 A66 L81 L82 N83 Q84 E86 E97 G98 Y99 T100 W112 C113 K114 K123 K124 Q125

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

External links

• PDB: RCSB:8vsa, PDBe:8vsa, PDBj:8vsa
• PDBsum: 8vsa
• PubMed: 38500588
• UniProt: A0A2X1N680