Structure of PDB 8xt0 Chain SB Binding Site BS02

Receptor Information

>8xt0 Chain SB (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FNDKILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIF
GSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIEN
MARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNIFEPHV
AVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRLFQTAI
TRAKEKRQQVEALYRLQ

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8xt0 Chain SB Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	H93 D224 D241
Binding residue (residue number reindexed from 1)	H36 D167 D184
Annotation score	4

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0032543	mitochondrial translation
GO:0061668	mitochondrial ribosome assembly

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005763	mitochondrial small ribosomal subunit
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum	8xt0
PubMed	38942792
UniProt	Q9Y399\|RT02_HUMAN Small ribosomal subunit protein uS2m (Gene Name=MRPS2)

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