Structure of PDB 8ihl Chain S Binding Site BS02

Receptor Information

>8ihl Chain S (length=104) Species: 9606 (Homo sapiens)

AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLP

Ligand information

>8ihl Chain J (length=353)

atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagctcgagcctggagactagggagtaatcc
ccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtg
ctagagctgtctacgaccaattgagctcgagcctggagactagggagtaa
tccccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcg
gtgctagagctgtctacgaccaattgagcggcctcggcaccgggattctc
gat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ihl Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties.
• Resolution: 7.64 Å
• Binding residue (original residue number in PDB): K15 T16 G28 R29 R32 E41 R77
• Binding residue (residue number reindexed from 1): K2 T3 G15 R16 R19 E28 R64

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0008285 negative regulation of cell population proliferation
• GO:0031507 heterochromatin formation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8ihl, PDBe:8ihl, PDBj:8ihl
• PDBsum: 8ihl
• PubMed: 38191828
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)