Structure of PDB 8fru Chain S Binding Site BS02

Receptor Information

>8fru Chain S (length=173) Species: 941442 (Giardia intestinalis assemblage A)

MMQKYIVYGRRLPSEKFPEPEVFRMTIYAPNEIVAKSRFWYHLKSLKKIK
RTHGEILDCQHIEENGDFVKNFGVLLRYRSRVGQHNMYREVRETTSARAM
DKVYSEMAGQCRARYHDIQIINVKEVADEDVRREKVAMFTQKGVRFPHPC
PYVHVKRAARTARFQDRAPHVPQ

Ligand information

>8fru Chain 1 (length=2551)

cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguac
gccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgg
gaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggc
ccgagggccccgcccgagagggugcaagccccguacggcgggcggcgagu
agcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcu
aaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacgguga
aaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccgg
cccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcg
agcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccg
ccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaa
aggcggugaucuaugcccggcgagggcgaggccgggcgaaagccuggugg
aggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugg
gggcgaaagacucaucgaaccgccugguagcugguugccuccgaaauguc
ucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccgg
cgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccc
cgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccu
ccugguaagcaggacgggcgaggcgggacgauccggacgccgggccaggg
ugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccg
aaucggccggcccggaaaauggagcgcgccggagccccggacccgcgccc
ggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaagg
cggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcag
uagccgcuacuccgcgccccggaggacugagggggagacggguuccgcgg
cgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagacc
gggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggc
aggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggac
cgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgcc
uugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgcc
ccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcagga
cuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagu
cggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgg
gucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacag
cgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagug
ccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcggg
aguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuucc
gacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuc
cgcgagccuccagccucgggaacgggcgagggccggccagcggggcaaga
agacccuuuugagcuugacuccagcccgggccuguggggcgggggccgcc
gccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucg
gcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggc
ucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccg
acccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauc
cuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagg
gauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugau
ccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgu
cggauuguucacccguucaagggaucgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuggccccggggccagagcacggcgggcc
aguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggc
cgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucua
agcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgug
ccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuc
cuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcg
c

........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>
>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<
......>>>>>((......<<<.....))>>>...>>>>>>>>.......
.<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]].
.................................<<....>>.........
.......<<<....>>>............................<<<<<
<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<.
.<<<...<<<....>>>..>>>...<<....>>............<<<<<
<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..
<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>..
...>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>..
.<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<
<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<
<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<
<(((...<<<<<<<........<<<.<<<<<<<<<...............
..>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>
>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<
<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<...
..<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<
...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>
......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>
))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<
<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.
....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.
........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.
>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<
<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<
<<<.......>>>>>>........<...........<<<<<<.....>>>
>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>
>>>....>>....<<<<<........>>>>>...((((((..{{{.....
....{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<........
.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...
<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<
...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>..
.<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......
(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<.
..............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}
.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........
>>>>>>...>>>..>>>..>>>>>....<<<<<<................
............>>>>>>.....<<<<<.......>>>>..<<<<<<<<<
<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>..
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fru The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
• Resolution: 2.49 Å
• Binding residue (original residue number in PDB): R113 Y120 R121 S137 A140 G141 Q142 R144 R146 R165 Y184 R192 Q197 D198 R199 H202 P204
• Binding residue (residue number reindexed from 1): R81 Y88 R89 S105 A108 G109 Q110 R112 R114 R133 Y152 R160 Q165 D166 R167 H170 P172

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fru, PDBe:8fru, PDBj:8fru
• PDBsum: 8fru
• PubMed: 38242118
• UniProt: V6TB90