Structure of PDB 8cvo Chain S Binding Site BS02

Receptor Information
>8cvo Chain S (length=60) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTALKVKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRICLREMAHAG
QLPGVTKSSW
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8cvo Chain S Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cvo Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		C24 C27 C40 C43
Binding residue
(residue number reindexed from 1)		C23 C26 C39 C42
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cvo, PDBe:8cvo, PDBj:8cvo
PDBsum8cvo
PubMed36864821
UniProtQ6A6N9|RS14Z_CUTAK Small ribosomal subunit protein uS14B (Gene Name=rpsZ)

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