Structure of PDB 7qv3 Chain S Binding Site BS02

Receptor Information

>7qv3 Chain S (length=109) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

QAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAASPIIEKVL
KSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTS
HITIVVSEK

Ligand information

>7qv3 Chain V (length=2887)

guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaug
aaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuug
auccggagauuuccgaauggggaaacccaccacucguaauggagugguau
ccauaucugaauucauaggauaugagaaggcagacccggggaacugaaac
aucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcgg
cgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguugu
aggacacucgaacgagguagaugaagaggucuggaaaggcccgccauagg
agguaacagcccuguagucaaaacuucguucgaguggauccugaguacgg
cggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcu
aaauacucccuagugaccgauagugaaccaguaccgugagggaaagguga
aaagcaccccggaaggggagugaaagagauccugaaaccgugugccuaca
aguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaac
cggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcag
cgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaa
ccaggugaucuacccauguccagggugaaguucagguaacacugaaugga
ggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggg
gugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuu
uagggcuagccucaagguaagagucuuggagguagagcacugauuggacu
aggggccccuaccggguuaccgaauucagucaaacuccgaaugccaauga
cuuauccuugggagucagacugcgagugauaagauccguagucgaaaggg
aaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaa
aggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccac
cauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaa
auguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagug
guaggagagcguucuaagggcugugaagccagaccggaaggacuggugga
gcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaau
ccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucagg
guuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacag
guugauauuccuguaccaccuccucaccauuugagcaauggggggacgca
ggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggc
ugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcg
cgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagag
gugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggu
gaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuuc
gggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaa
uaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaa
ggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggag
cgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccg
uaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccga
cccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucgg
ugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaa
gaccccguggagcuuuacugcagccugauauugaauguugguacagcuug
uacaggauagguaggagccuuggaaaccggagcgccagcuucgguggagg
caucggugggauacuacccuggcuguauugaccuucuaacccaccgcccu
uaucgggcggggagacagugucaggugggcaguuugacuggggcggucgc
cuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaa
aucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuaca
agucgagcagggacgaaagucgggcuuagugauccggugguuccgcaugg
aagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuau
cucccccaagaguccacaucgacggggagguuuggcaccucgaugucggc
ucaucgcauccuggggcuguagucggucccaaggguugggcuguucgccc
auuaaagcgguacgcgagcuggguucagaacgucgugagacaguucgguc
ccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacga
gaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggc
aucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagc
augaagccccccucaagaugagauuucccauuccgcaaggaaguaagauc
ccugaaagaugaucagguugauaggucugagguggaaguguggcgacaca
uggagcugacagauacuaaucgaucgaggacuuaacc

.<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<....
..<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<
<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<...
.>>......>>>>>.>.........<<....>>...<<<<......<<..
...>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......
<<<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......
<<<.....))>>>...>>>...>>>>>>>>..>>>>..>>>>.....<<<
<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).
.....]].>>>>>>>.]]...............<<....>>....]]...
......<<<<....>>>>.............}....>>>>>>>>>>>...
....<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<
<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<
<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<
<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...
>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<
<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<.
...>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<..
.<<<<.<<.....>>.>>.>>...>>>>>>>>..>>.>.....>>>>.>>
>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<
......>>>...<<<<.<<<...<<<(((.....<<<<<<..........
.<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>..
.>>.........<<......>>...>>>>>...>>>>>>>>>>.>>....
.......))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>.
...>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>...
.>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......
>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>
....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<
<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<
<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<
<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..
>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>
>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>
>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..
>......>>>>><<<<.....<<<<....>>>>....>>>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....
>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<....<
<<<<..<<....>>...>>>>>....>...>>>>>>>>..>>>>><<<<<
.........>>>>>........<...........<<<<<<.....>>>>>
>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>
>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[...
...<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<.<...
..........<.<<..<<<......<<<<<<<<....>>>>>>>>...>>
>............>>.>...>..>>>>>>>>>.>>>....<<.<<<<<<.
....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<
<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<......
.>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<.....
.>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>
..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.
<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<
.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>
>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....
]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<........
.......>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>
>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>
>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<
<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>
>...>>>..>>>>>.>>>...>>>>....>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qv3 Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue.
• Resolution: 5.14 Å
• Binding residue (original residue number in PDB): K4 A7 R8 R15 K16 R18 R41 A42 K49 S53 A56 N57 H60 N61 D77 E78 K83 R84 R86 P87 R88 A89 M90 G91 A93 Q95 N97 K98 R99
• Binding residue (residue number reindexed from 1): K3 A6 R7 R14 K15 R17 R40 A41 K48 S52 A55 N56 H59 N60 D76 E77 K82 R83 R85 P86 R87 A88 M89 G90 A92 Q94 N96 K97 R98

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qv3, PDBe:7qv3, PDBj:7qv3
• PDBsum: 7qv3
• PubMed: 35264791
• UniProt: P42060|RL22_BACSU Large ribosomal subunit protein uL22 (Gene Name=rplV)