Structure of PDB 7nhl Chain S Binding Site BS02

Receptor Information
>7nhl Chain S (length=114) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIK
RRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYY
LRSLRGKAARIQEI
Ligand information
>7nhl Chain a (length=1538) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauaca
ugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcg
gacgggugaguaacacguggauaaccuaccuauaagacugggauaacuuc
gggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaa
gugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagc
uaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccuga
gagggugaucggccacacuggaacugagacacgguccagacuccuacggg
aggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaac
gccgcgugagugaugaaggucuucggaucguaaaacucuguuauuaggga
agaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaa
agccacggcuaacuacgugccagcagccgcgguaauacguagguggcaag
cguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagu
cugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaa
aacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaug
cgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucugua
acugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccu
gguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgc
cccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgac
cgcaagguugaaacucaaaggaauugacggggacccgcacaagcggugga
gcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugaca
uccuuugacaacucuagagauagagccuuccggacaaagugacagguggu
gcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaa
cgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaag
uugacugccggugacaaaccggaggaagguggggaugacgucaaaucauc
augccccuuaugauuugggcuacacacgugcuacaauggacaauacaaag
ggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguuc
ggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucg
uagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcc
cgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuu
aggagcuagccgucgaaggugggacaaaugauuggggugaagucguaaca
agguagccguaucggaaggugcggcuggaucaccuccu
...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.
<<<..<<<..<<.<<<<...<<<.........>.>>...>>>>.>>>>>.
.....<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<
<<....>>>.>>......>>>>......<<<.<<<<<<..>>>>>>>>>.
......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<
<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..
..>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>
>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>
>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<..
.....<.<<<<<<<........>>>>>>>.>........>>>>>>...>.
.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>
>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<
<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>
>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>
>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.
>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>
>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>
>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<
<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<
<<<<<<<<<......<<........>>..........<<<<<<<......
<<<<<<.....<<<<<....>>>>>..........>>>>.>>.<<<.<<<
..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>
>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>
>>.....<<<<<.....>>>>>........>>>>.........>>>...>
>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<
<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<
..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<
<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...
>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.
....<<<<<<<<<....>>>>>>>>>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7nhl Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R41 G107 K108 R111
Binding residue
(residue number reindexed from 1)		R40 G106 K107 R110
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nhl, PDBe:7nhl, PDBj:7nhl
PDBsum7nhl
PubMed34117249
UniProtQ2FZ42|RL19_STAA8 Large ribosomal subunit protein bL19 (Gene Name=rplS)

[Back to BioLiP]