Structure of PDB 6la2 Chain S Binding Site BS02

Receptor Information
>6la2 Chain S (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSI
KRLVTTGVLKQTKGVGASGSFRLAK
Ligand information
>6la2 Chain J (length=343) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctgttttttttcatgtgccggtctcacacgtgcctggagactagtaag
cgcttctagtggcggttaaaacgcggtagacagcgcgtacgtgcgtttaa
gcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggatg
cgttttttttttcatactcgagcatgcttttttttttcatgtgccggtct
cacacgtgcctggagactagtaagcgcttctagtggcggttaaaacgcgg
tagacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaa
ttgagcggcctcggcaccgggatgcgttttttttcagcggtac
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6la2 Engineering nucleosomes for generating diverse chromatin assemblies.
Resolution3.89 Å
Binding residue
(original residue number in PDB)		K27 Y28 S46 Q48 S49 N63 R74
Binding residue
(residue number reindexed from 1)		K5 Y6 S24 Q26 S27 N41 R52
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0030261 chromosome condensation
GO:0031507 heterochromatin formation
GO:0045910 negative regulation of DNA recombination
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0017053 transcription repressor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6la2, PDBe:6la2, PDBj:6la2
PDBsum6la2
PubMed33590100
UniProtP07305|H10_HUMAN Histone H1.0 (Gene Name=H1-0)

[Back to BioLiP]