Structure of PDB 6fec Chain S Binding Site BS02

Receptor Information
>6fec Chain S (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKI
YKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGH
DILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILIL
QNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEY
IVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVL
KVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG
VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEG
DKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVG
EKIALSRRVEKHWRLIGWGQIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fec Structure of a human cap-dependent 48S translation pre-initiation complex.
Resolution6.3 Å
Binding residue
(original residue number in PDB)		I205 E210 A213 Y217 P233 I234 P236 I237 Y243 N244 E246 V247
Binding residue
(residue number reindexed from 1)		I154 E159 A162 Y166 P182 I183 P185 I186 Y192 N193 E195 V196
Enzymatic activity
Catalytic site (original residue number in PDB) A64 K67 S68 T91 H151
Catalytic site (residue number reindexed from 1) A13 K16 S17 T40 H100
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum6fec
PubMed29401259
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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