Structure of PDB 6ezj Chain S Binding Site BS02

Receptor Information
>6ezj Chain S (length=185) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIGEVKRETKETNVSVKINLDGHGVSDSSTGIPFLDHMLDQLASHGLFDV
HVRATGDTHIDDHHTNEDVALAIGTALLKALGERKGINRFGDFTAPLDEA
LIHVSLDLSGRPYLGYNLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTLHI
RQLAGKNSHHIIEATFKAFARALRQATESDPRRGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6ezj Chain S Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ezj Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H73 E77 H145
Binding residue
(residue number reindexed from 1)		H63 E67 H135
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
Biological Process
GO:0000105 L-histidine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6ezj, PDBe:6ezj, PDBj:6ezj
PDBsum6ezj
PubMed29434040
UniProtO23346|HIS5B_ARATH Imidazoleglycerol-phosphate dehydratase 2, chloroplastic (Gene Name=HISN5B)

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