Structure of PDB 5jfc Chain S Binding Site BS02

Receptor Information
>5jfc Chain S (length=279) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMFKILRKERLAPGINLFEIESPRIAKHAKPGQFVMIRLHEKGERIPLTI
ADVDISKGSITIVAQEVGKTTRELGTYEAGDYILDVLGPLGKPSHIDYFG
TVVMIGGGVGVAEIYPVAKAMKEKGNYVISILGFRTKDLVFWEDKLRSVS
DEVIVTTNDGSYGMKGFTTHALQKLIEEGRKIDLVHAVGPAIMMKAVAEL
TKPYGIKTVASLNPIMVDGTGMCGACRVTVGGEVKFACVDGPEFDAHLVD
WDQLMNRLAYYRDLEKISLEKWERERRMV
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5jfc Chain S Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jfc Mechanistic insights into energy conservation by flavin-based electron bifurcation.
Resolution1.598 Å
Binding residue
(original residue number in PDB)		M221 D223 G224 G226 C228 G229 C231 C243
Binding residue
(residue number reindexed from 1)		M216 D218 G219 G221 C223 G224 C226 C238
Annotation score3
Enzymatic activity
Enzyme Commision number 1.18.1.2: ferredoxin--NADP(+) reductase.
1.8.1.19: sulfide dehydrogenase.
Gene Ontology
Molecular Function
GO:0004324 ferredoxin-NADP+ reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jfc, PDBe:5jfc, PDBj:5jfc
PDBsum5jfc
PubMed28394885
UniProtQ8U194|SUDHB_PYRFU Sulfide dehydrogenase subunit beta (Gene Name=sudB)

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