Structure of PDB 2glj Chain S Binding Site BS02

Receptor Information

>2glj Chain S (length=456) Species: 1488 (Clostridium acetobutylicum)

LLKEYKNAWDKYDDKQLKEVFALGDRFKNFISNCKTERECVTELIKTAEK
SGYRNIEDILAKGETLKEGDKVYANNRGKGLIMFLIGKEPLYTGFKILGA
HIDSPRLDLKQNPLYEDTDLAMLETHYYGGIKKYQWVTLPLAIHGVIVKK
DGTIVNVCVGEDDNDPVFGVSDILVHLASEQLEKKASKVIEGEDLNILIG
SIPLKDGEEKQKVKHNIMKILNEKYDISEEDFVSAELEIVPAGKARDYGF
DRSMVMGYGQDDRICAYTSFEAMLEMKNAKKTCITILVDKEEVGSIGATG
MQSKFFENTVADIMSDELKLRKALYNSEMLSSDVSAAFDPNYPNVMEKRN
SAYLGKGIVFNKYTGSRGKSGCNDANPEYIAELRRILSKESVNWQTAELG
KVDQGGGGTIAYILAEYGMQVIDCGVALLNMHAPWEISSKADIYETKNGY
SAFLNN

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2glj Chain S Residue 6038

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2glj crystal structure of aminopeptidase I from Clostridium acetobutylicum
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): H105 D265 E295 E296 D342
• Binding residue (residue number reindexed from 1): H101 D261 E291 E292 D333
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.11.-

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2glj, PDBe:2glj, PDBj:2glj
• PDBsum: 2glj
• UniProt: Q97K30|APEA_CLOAB Probable M18 family aminopeptidase 1 (Gene Name=apeA)