Structure of PDB 7d63 Chain RJ Binding Site BS02 |
| >7d63 Chain RJ (length=796) Species: 559292 (Saccharomyces cerevisiae S288C)
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TMQRSSDVNERKLHVPMVDRTPEDDPPPFIVAVVGPPGTGKTTLIRSLVR
RMTKSTLNDIQGPITVVSGKHRRLTFLECPADDLNAMIDIAKIADLVLLL
IDGNFGFEMETMEFLNIAQHHGMPRVLGVATHLDLFKSQSTLRASKKRLK
HRFWTEVYQGAKLFYLSGVINGRYPDREILNLSRFISVMKFRPLKWRNEH
PYMLADRFTDLTHPELIETQGLQIDRKVAIYGYLHGTPLPSAPGTRVHIA
GVGDFSVAQIEKLPDPCPTPFRKRLDDKDKLIYAPMSDVGGVLMDKDAVY
IDIERGEGEKLMTGLQSVEQSIAEKFDGVNIGKLIYMDNISPEECIRRWR
DLEKFVPYFDTFEKLAKKWKSVDAIKERFLTWYELQKAKISKQLEINNIE
YQEMTPEQRQRIEGFKAGSYVRIVFEKVPMEFVKNFNPKFPIVMGGLLPT
EIKFGIVKARLRRHRWHKKILKTNDPLVLSLGWRRFQTLPIYTTTDSRTR
TRMLKYTPEHTYCNAAFYGPLCSPNTPFCGVQIVANSDTGNGFRIAATGI
VEEIDVNIEIVKKLKLVGFPYKIFKNTAFIKDMFSSAMEVARFEGAQIKT
VSGIRGEIKRALSKPEGHYRAAFEDKILMSDIVILRSWYPVRVKKFYNPV
TSLLLKEKTEWKGLRLTGQIRAAMNLETPSNPDSAYHKIERVERHFNGLK
VPKAVQKELPFKSQIHQMKPQKKKTYMAKRAVVLGGDEKKARSFIQKVLT
ISKAKDSKRKEQKASQRKERLKKLAKMEEEKSQRDKEKKKEYFAQN |
|
| >7d63 Chain SA (length=1331)
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|
aagauaguuaucugguugauccugccaguagucauaugcuugucucagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucau
uaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauu
cuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggccaaauuacccaauccuaauucagggagguagugacaauaaaua
acgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaa
uaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguagu
ugaacuggcccgguuggccgguccggauuuccaacggggccuugguucua
uuuucuaggacugauuaauagggacggucgggggcaucaguauucaauug
ucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcau
uugccaaggacguuuucauuaaucaagaacgccgacuagggaucgggugg
uguuuuuuuaaugacccacucggcaccuuacgagacuggggggaguaugg
ucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggagug
gagccugcggcucaacacggggaaacucaccagguccagacacaauaagg
auugacauucuugauuuugugggugguggugcauugaugcccuuguucug
ggccacgcgcgcuacacugacggagccagcgagucuacccuuggccgaga
ggucuugggugaaacuccgucgugcuggggauagagcauuguaauuauug
cucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugau
uacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaaug
gcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucuca
gagcggagaauuuggacaaacuuggucauuuagaggaacuaaaaguuucc
guaggugaaccugcggaaggaucauuaaaga |
............................<<<<.<<<<<<........<<<
.<<...<<....<<....<<..........>>...>>.>>.....<<<..
.....<<<..<<..<<....<<<..........<.....<<.<<......
.>>.>>......>.......<<<<............>>>>.....<<<<<
...<<<<..............>>>>...>>>>>.........<<<<...<
<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<
<<<<<<.......>>>>>>>>>>>......>>>.....<<..........
.....>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>..
..>>>>>......<<<....<<<.....>>>..>>>..............
.<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.......
....>..>>.........<<<<<<.......<<<....>>>.........
.........>>>>>>..>>>>>>>>>>.........<....<.<<...<<
<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<
...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<
...<<<......>>>......>.>>>>>>..>>.......<<....>>..
.>>>>...>>>>>.>>>...>>>...>>.>..<<...<<<..<<<<<<<<
.<<<........>>>>>>>>>>>..>>>..>>.....>............
........<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<.
.<<<.<<<<.......................<<.<....<<<<<.....
...<.....>......>>>>>......<<<........>>>...>.>>..
.....>>>>.>>>.....<<<<<<<.............<<..<<<<....
>>>>..>>......>>>>>>>...........<<<<<<..........>>
>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>...
...>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<
<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...
>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>.....<<<<
<<<<<....>>>>>>>>>............. |
|
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| PDB | 7d63 Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) |
| Resolution | 12.3 Å |
Binding residue
(original residue number in PDB) | R45 R52 R92 R166 F177 T182 R184 H192 Y199 G201 K203 L204 F205 Y206 N222 R225 F226 S228 V229 R346 K837 I838 T862 D864 S865 R868 R870 L872 K873 Y874 T879 K931 K933 F942 K943 T945 F947 K967 R973 K977 R978 S981 R988 E992 D993 K994 M997 R1004 R1039 T1046 P1047 S1052 Y1054 K1123 K1126 R1127 R1135 R1138 L1142 D1153 K1156 K1158 F1161 A1162 |
Binding residue
(residue number reindexed from 1) | R4 R11 R51 R125 F136 T141 R143 H151 Y158 G160 K162 L163 F164 Y165 N181 R184 F185 S187 V188 R274 K469 I470 T494 D496 S497 R500 R502 L504 K505 Y506 T511 K563 K565 F574 K575 T577 F579 K599 R605 K609 R610 S613 R620 E624 D625 K626 M629 R636 R671 T678 P679 S684 Y686 K755 K758 R759 R767 R770 L774 D785 K788 K790 F793 A794 |
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| Enzyme Commision number |
? |
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Biological Process |
| GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0000472 |
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0000479 |
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0000480 |
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0030490 |
maturation of SSU-rRNA |
| GO:0042254 |
ribosome biogenesis |
| GO:0042274 |
ribosomal small subunit biogenesis |
| GO:2000232 |
regulation of rRNA processing |
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