Structure of PDB 9ija Chain R Binding Site BS02
Receptor Information
>9ija Chain R (length=284) Species:
9606
(Homo sapiens) [
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MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTA
LAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLA
TGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINI
HINASINGRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHT
VKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILS
QVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLR
Ligand information
Ligand ID
CLR
InChI
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey
HVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04
OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0
CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341
CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
Formula
C27 H46 O
Name
CHOLESTEROL
ChEMBL
CHEMBL112570
DrugBank
DB04540
ZINC
ZINC000003875383
PDB chain
9ija Chain R Residue 502 [
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Receptor-Ligand Complex Structure
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PDB
9ija
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Resolution
3.05 Å
Binding residue
(original residue number in PDB)
F76 F82 W89 V180 T184 I187 S265 G269
Binding residue
(residue number reindexed from 1)
F76 F82 W89 V165 T169 I172 S250 G254
Annotation score
4
Gene Ontology
Molecular Function
GO:0004930
G protein-coupled receptor activity
GO:0008527
taste receptor activity
GO:0033038
bitter taste receptor activity
Biological Process
GO:0001580
detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186
G protein-coupled receptor signaling pathway
GO:0050909
sensory perception of taste
Cellular Component
GO:0005886
plasma membrane
GO:0016020
membrane
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:9ija
,
PDBe:9ija
,
PDBj:9ija
PDBsum
9ija
PubMed
38969802
UniProt
Q9NYV8
|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)
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