Structure of PDB 9fmd Chain R Binding Site BS02

Receptor Information
>9fmd Chain R (length=328) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSPPPYGYRKGWIPRLLED
FGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQS
KDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQ
KVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPM
EPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNA
KGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQ
VERKMAQKEKEKHEEKLREMAQKARERR
Ligand information
>9fmd Chain 6 (length=97) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu
<<<<<.<<....>>>>>>>...............................
......<<...<<<.....>>>....>>...................
Receptor-Ligand Complex Structure
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PDB9fmd Mechanism for the initiation of spliceosome disassembly.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		M202 K217 I218 P219 N256 K258
Binding residue
(residue number reindexed from 1)		M195 K210 I211 P212 N249 K251
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0016922 nuclear receptor binding
GO:0019899 enzyme binding
GO:0042809 nuclear vitamin D receptor binding
GO:0042974 nuclear retinoic acid receptor binding
GO:0046332 SMAD binding
GO:0050681 nuclear androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000398 mRNA splicing, via spliceosome
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043923 positive regulation by host of viral transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048384 retinoic acid receptor signaling pathway
GO:0048385 regulation of retinoic acid receptor signaling pathway
GO:0050769 positive regulation of neurogenesis
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0070564 positive regulation of vitamin D receptor signaling pathway
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0008024 cyclin/CDK positive transcription elongation factor complex
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Cellular Component
External links
PDB RCSB:9fmd, PDBe:9fmd, PDBj:9fmd
PDBsum9fmd
PubMed38925148
UniProtQ13573|SNW1_HUMAN SNW domain-containing protein 1 (Gene Name=SNW1)

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