Structure of PDB 8uxx Chain R Binding Site BS02

Receptor Information

>8uxx Chain R (length=370) Species: 9986 (Oryctolagus cuniculus)

TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVG
DEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLL
TEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDS
GDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAE
REIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERF
RCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTM
YPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQM
WITKQEYDEAGPSIVHRKCF

Ligand information

• Ligand ID: BEF
• InChI: InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
• InChIKey: OGIAHMCCNXDTIE-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [Be-](F)(F)F
  ACDLabs 10.04
  CACTVS 3.341: F[Be-](F)F
• Formula: Be F3
• Name: BERYLLIUM TRIFLUORIDE ION
• PDB chain: 8uxx Chain R Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8uxx High resolution cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by the Arp2/3 complex
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): S14 Q137 G156 D157 G158
• Binding residue (residue number reindexed from 1): S9 Q132 G151 D152 G153
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0030240 skeletal muscle thin filament assembly
• GO:0048741 skeletal muscle fiber development

Cellular Component

• GO:0001725 stress fiber
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005865 striated muscle thin filament
• GO:0005884 actin filament

External links

• PDB: RCSB:8uxx, PDBe:8uxx, PDBj:8uxx
• PDBsum: 8uxx
• PubMed: 38448439
• UniProt: P68139|ACTS_CHICK Actin, alpha skeletal muscle (Gene Name=ACTA1)