Structure of PDB 8scb Chain R Binding Site BS02

Receptor Information
>8scb Chain R (length=179) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIR
KPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRIL
RRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARK
KLLADQAEARRSKTKEARKRREERLQAKK
Ligand information
>8scb Chain 9 (length=1692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
cccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugg
uagucgccgugccuaccauggugaccacgggugacggggaaucaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaau
aacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuua
aauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgc
gguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagc
ucguaguuggaucuugggagcgggcguccccgccuuuacuuugaaaaaau
uagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaaua
auggaauaggaccgcgguucuauuuugguuuucggaacugaggccaugau
uaagagggacggccgggggcauucguauugcgccgcuagaggugaaauuc
uuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuu
ucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccguc
guaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucc
caugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggg
ggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacc
cggcccggacacggacaggauugacagauugauagcucuuucucgauucc
gugggugguggugcauggccguucuuaguugguggagcgauuugucuggu
uaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccc
ccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagc
cacccgagauugagcaauaacaggucugugaugcccuuagauguccgggg
cugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccgg
caggcgcggguaacccguugaaccccauucgugauggggaucggggauug
caauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcu
ugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuacc
gauuggaugguuuagugaggcccucggaucggccccgccggggugcccug
gcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaag
ucguaacaagguuuccguaggugaaccugcggaaggaucauu
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<.......<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>>....<<<<<...<......>..>>>>>............<<<.<<<<.
.....>>>>>>>...>>>>...>>..>.>>>.<<<....<<<....<<<<
<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>...
..<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<.....
......>..>>.........<<<<<((......<<<<.....<<..))>>
.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.
<<...<<<.<<.....<<.<.<<....>>.>.>>.<<<<<<.<.......
<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>
>.......<<.<..<<<<<<<............>>>>>>>.>.>>....>
>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>
......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>
>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>
...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<.....
...>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<
<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<
<..<<<<<..<<<.<<<<<<......<<........>>..........<<
<<<.<....<<<..........<<.<<<........>>>.>>........
>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<.
.....>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<..
.<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>
>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>.
..>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<..
..>>>>.>>>....>.........>>>.>>......<...<.<<<<<...
.......>>>>>>....>.....>>>>>.....<<<<<<<<.......>>
>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<
....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>
>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>
.>>...>.....<<<<<<<<<<..>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8scb Structure and consequences of eRF1 glued to the ribosomal decoding center
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R163 T166 R172 R173 R176
Binding residue
(residue number reindexed from 1)		R161 T164 R170 R171 R174
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8scb, PDBe:8scb, PDBj:8scb
PDBsum8scb
PubMed38172604
UniProtG1TJR3

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