Structure of PDB 8qp8 Chain R Binding Site BS02

Receptor Information
>8qp8 Chain R (length=106) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRT
GKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVR
KKQKEK
Ligand information
>8qp8 Chain 4 (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuugcuaauugaaaacuucccaaua
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>........................
Receptor-Ligand Complex Structure
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PDB8qp8 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution3.5 Å
Binding residue
(original residue number in PDB)		I413 K416 S457 M458
Binding residue
(residue number reindexed from 1)		I45 K48 S89 M90
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qp8, PDBe:8qp8, PDBj:8qp8
PDBsum8qp8
PubMed38778104
UniProtQ9BTD8|RBM42_HUMAN RNA-binding protein 42 (Gene Name=RBM42)

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