Structure of PDB 8ioc Chain R Binding Site BS02

Receptor Information
>8ioc Chain R (length=272) Species: 9606,392809 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVAD
MLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICN
LLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSE
SKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPQHSCMKGA
VTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCN
SVIDPLIYAFRSLELRNTFREI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8ioc Chain R Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ioc Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		E94 D117 D121
Binding residue
(residue number reindexed from 1)		E60 D83 D87
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0042923 neuropeptide binding
Biological Process
GO:0002027 regulation of heart rate
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0019222 regulation of metabolic process
GO:0032922 circadian regulation of gene expression
GO:0042309 homoiothermy
GO:0045475 locomotor rhythm
GO:0048511 rhythmic process
GO:0055078 sodium ion homeostasis
GO:0060259 regulation of feeding behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ioc, PDBe:8ioc, PDBj:8ioc
PDBsum8ioc
PubMed37524700
UniProtP03435;
P41968

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