Structure of PDB 8inr Chain R Binding Site BS02

Receptor Information

>8inr Chain R (length=271) Species: 9606,392809

IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSM
SSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIA
VDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVI
LCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASRTSMQGAVTVT
MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMD
PLIYAFRSQEMRKTFKEIICC

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8inr Chain R Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8inr Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
• Resolution: 2.73 Å
• Binding residue (original residue number in PDB): E92 D115 D119
• Binding residue (residue number reindexed from 1): E55 D78 D82
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004977 melanocortin receptor activity
• GO:0005515 protein binding
• GO:0042562 hormone binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0019222 regulation of metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8inr, PDBe:8inr, PDBj:8inr
• PDBsum: 8inr
• PubMed: 37524700
• UniProt: P03435;
  P33032