Structure of PDB 8f7k Chain R Binding Site BS02

Receptor Information
>8f7k Chain R (length=230) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKK
VRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTY
GSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDP
AGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEE
GEELKAPEIASITVGNKYRIYDQEEVKKFL
Ligand information
Ligand IDXIB
InChIInChI=1S/C20H22N2O6/c1-13(19(25)26)21-18(24)17(11-14-7-9-16(23)10-8-14)22-20(27)28-12-15-5-3-2-4-6-15/h2-10,13,17,23H,11-12H2,1H3,(H,21,24)(H,22,27)(H,25,26)/t13-,17+/m1/s1
InChIKeyLKRYTYVDKGHSPS-DYVFJYSZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C[C@H](C(=O)O)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)OCc2ccccc2
CACTVS 3.385C[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc2ccccc2)C(O)=O
OpenEye OEToolkits 2.0.7CC(C(=O)O)NC(=O)C(Cc1ccc(cc1)O)NC(=O)OCc2ccccc2
CACTVS 3.385C[CH](NC(=O)[CH](Cc1ccc(O)cc1)NC(=O)OCc2ccccc2)C(O)=O
ACDLabs 12.01Oc1ccc(CC(NC(=O)OCc2ccccc2)C(=O)NC(C)C(=O)O)cc1
FormulaC20 H22 N2 O6
NameN-[(benzyloxy)carbonyl]-L-tyrosyl-D-alanine
ChEMBL
DrugBank
ZINCZINC000004762089
PDB chain8f7k Chain S Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f7k High resolution structures define divergent and convergent mechanisms of archaeal proteasome activation.
Resolution1.94 Å
Binding residue
(original residue number in PDB)		G19 R28
Binding residue
(residue number reindexed from 1)		G16 R25
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f7k, PDBe:8f7k, PDBj:8f7k
PDBsum8f7k
PubMed37454196
UniProtP25156|PSA_THEAC Proteasome subunit alpha (Gene Name=psmA)

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