Structure of PDB 8c3a Chain R Binding Site BS02

Receptor Information
>8c3a Chain R (length=129) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVDATAPKKRTFKQFSFKGVDLKDLVEMPTEEFTKLCGARVRRRFSRGLD
SKPMGLIKKLRAARAATEPNERPAVVKTHLRNMIVVPEMIGSVVGVYNGK
VFNTVEIKPEMVGHYLGEFSITYTPVRHG
Ligand information
>8c3a Chain B (length=1761) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgu
gguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaaggga
uguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucau
aauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaau
uucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuca
acggguaacggggaauaaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccga
cacggggagguagugacaauaaauaacgauacagggcccuuuugggucuu
guaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauau
uaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcugg
ccgguccgcguacuggacccagccgagccuuuccuucuggguagccauuu
auggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcagg
ccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguu
cuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgg
ggguaucaguauucaguugucagaggugaaauucuuggauuuacugaaga
cuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacg
aaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaa
acuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggca
ccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacggggaaacucaccagguccagacacaaua
aggauugacagauugagagcucuuucuugauuuugugggugguggugcau
ggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaa
cgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauaguca
cuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaa
caggucugugaugcccuuagacguucugggccgcacgcgcgcuacacuga
cggagccagcgaguauaagccuuggccgagaggucugggaaaucuuguga
aacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgag
gaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcc
cuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggc
cuccggauugguuuaggaaauucuggaaccgagaagcuggucaaacuugg
ucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugc
ggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<...............<<.....<..<
<.......>>..>......>>........<<<<<..<<....>>..>>>>
><...<<<<<<.......((((((.<<<....>>>..............>
>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>
..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<.
..>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>
>>>.>>>......<<..<...........>..>>.........<<<<<((
......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>
>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<..
....................>>>>>>>>>>.....<<<<<..........
........>>>>>....<<<<<.<<.......<<...<.......>..<<
<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<
<<......))))))...>>>>>>>>>>>.....>>....<<<<<<.<<..
.<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..
>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>.
...<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.....
.....<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..
>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<
<<<<......<<........>>..........<<<<<......<<<<<..
......<<.<<<........>>>.>>......>>>>>...<<.<<<..<<
.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>
>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>
>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<
<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.....
..>>>>>>>......<....<<<<<<..........>>>>>>....>...
..>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>
>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<
<..<...<<<<<<.............>>>>>>...>..>>>>..>>>.>>
>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>
>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c3a New crystal system to promote screening for new eukaryotic inhibitors
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K18 A39 R40 R42 R43 R47 K59 K77 H79 R81 N82 N98 G99 K100 Y115 T122 Y123 T124 V126 H128
Binding residue
(residue number reindexed from 1)		K18 A39 R40 R42 R43 R47 K59 K77 H79 R81 N82 N98 G99 K100 Y115 T122 Y123 T124 V126 H128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000054 ribosomal subunit export from nucleus
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
PDBsum8c3a
PubMed
UniProtA0A1D8PK22|RS15_CANAL Small ribosomal subunit protein uS19 (Gene Name=RPS15)

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