Structure of PDB 7zx8 Chain R Binding Site BS02

Receptor Information

>7zx8 Chain R (length=222) Species: 9606 (Homo sapiens)

AERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGR
TEVSFTLNEDLANEHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAEC
RPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYE
RKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEI
LKEIGVQNVKGIHKNTWELKPE

Ligand information

>7zx8 Chain T (length=63)

cctgccaggtaagtatgctctgccccgacacagcctcatacgcctcactc
tttacacacacgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zx8 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): K214 K230
• Binding residue (residue number reindexed from 1): K198 K214

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0016251 RNA polymerase II general transcription initiation factor activity

Biological Process

• GO:0006366 transcription by RNA polymerase II
• GO:0006367 transcription initiation at RNA polymerase II promoter
• GO:0006368 transcription elongation by RNA polymerase II
• GO:0045944 positive regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005674 transcription factor TFIIF complex
• GO:0015630 microtubule cytoskeleton

External links

• PDB: RCSB:7zx8, PDBe:7zx8, PDBj:7zx8
• PDBsum: 7zx8
• PubMed: 36424526
• UniProt: P13984|T2FB_HUMAN General transcription factor IIF subunit 2 (Gene Name=GTF2F2)