Structure of PDB 7z8b Chain R Binding Site BS02
Receptor Information
>7z8b Chain R (length=86) Species:
9606
(Homo sapiens) [
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EVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAW
GVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
7z8b Chain R Residue 202 [
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Receptor-Ligand Complex Structure
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PDB
7z8b
Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
C75 H77 C94 D97
Binding residue
(residue number reindexed from 1)
C53 H55 C72 D75
Annotation score
4
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
2.3.2.32
: cullin-RING-type E3 NEDD8 transferase.
Gene Ontology
Molecular Function
GO:0004842
ubiquitin-protein transferase activity
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016740
transferase activity
GO:0019788
NEDD8 transferase activity
GO:0031625
ubiquitin protein ligase binding
GO:0034450
ubiquitin-ubiquitin ligase activity
GO:0046872
metal ion binding
GO:0060090
molecular adaptor activity
GO:0061629
RNA polymerase II-specific DNA-binding transcription factor binding
GO:0061630
ubiquitin protein ligase activity
GO:0061663
NEDD8 ligase activity
GO:0097602
cullin family protein binding
Biological Process
GO:0000165
MAPK cascade
GO:0000209
protein polyubiquitination
GO:0006281
DNA repair
GO:0006511
ubiquitin-dependent protein catabolic process
GO:0006513
protein monoubiquitination
GO:0006974
DNA damage response
GO:0007283
spermatogenesis
GO:0016567
protein ubiquitination
GO:0030163
protein catabolic process
GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032480
negative regulation of type I interferon production
GO:0034644
cellular response to UV
GO:0042110
T cell activation
GO:0043123
positive regulation of canonical NF-kappaB signal transduction
GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687
post-translational protein modification
GO:0045116
protein neddylation
GO:0045732
positive regulation of protein catabolic process
GO:0062197
cellular response to chemical stress
GO:0070936
protein K48-linked ubiquitination
GO:0071230
cellular response to amino acid stimulus
GO:0090090
negative regulation of canonical Wnt signaling pathway
GO:0140627
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1900076
regulation of cellular response to insulin stimulus
GO:1902499
positive regulation of protein autoubiquitination
GO:1902883
negative regulation of response to oxidative stress
GO:1904263
positive regulation of TORC1 signaling
Cellular Component
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0019005
SCF ubiquitin ligase complex
GO:0031461
cullin-RING ubiquitin ligase complex
GO:0031462
Cul2-RING ubiquitin ligase complex
GO:0031463
Cul3-RING ubiquitin ligase complex
GO:0031464
Cul4A-RING E3 ubiquitin ligase complex
GO:0031465
Cul4B-RING E3 ubiquitin ligase complex
GO:0031466
Cul5-RING ubiquitin ligase complex
GO:0031467
Cul7-RING ubiquitin ligase complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7z8b
,
PDBe:7z8b
,
PDBj:7z8b
PDBsum
7z8b
PubMed
35982156
UniProt
P62877
|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)
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