Structure of PDB 7u4d Chain R Binding Site BS02

Receptor Information
>7u4d Chain R (length=100) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILE
LAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAV
Ligand information
>7u4d Chain U (length=139) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gatgtatatatctgacacgtgcctggagactagggagtaatccccttggc
ggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctagagc
tgtctacgaccaattgagcggcctcggcaccggattctc
Receptor-Ligand Complex Structure
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PDB7u4d CENP-N promotes the compaction of centromeric chromatin.
Resolution8.1 Å
Binding residue
(original residue number in PDB)		K15 R17 R20 R32 R77
Binding residue
(residue number reindexed from 1)		K1 R3 R6 R18 R63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u4d, PDBe:7u4d, PDBj:7u4d
PDBsum7u4d
PubMed35422519
UniProtQ93077|H2A1C_HUMAN Histone H2A type 1-C (Gene Name=H2AC6)

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