Structure of PDB 7tfc Chain R Binding Site BS02

Receptor Information

>7tfc Chain R (length=443) Species: 1423 (Bacillus subtilis)

AKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGKALDNKVM
FDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDG
TPFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELN
DKGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKY
AGAVRSCDDIQTFKLVVKTIARKHGLHATFMPKPLFGVNGSGMHCNLSLF
KNGVNAFFDENADLQLSETAKHFIAGIVKHATSFTAVTNPTVNSYKRLVP
GYEAPCYVAWSAQNRSPLIRIPASRGISTRVEVRSVDPAANPYLALSVLL
AAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATLAEALEEFKS
NEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY

Ligand information

>7tfc Chain M (length=10) Species: 1423 (Bacillus subtilis)

TFRQGDMSRF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tfc Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Resolution: 1.96 Å
• Binding residue (original residue number in PDB): F60 R62 I63 E424 M427
• Binding residue (residue number reindexed from 1): F59 R61 I62 E423 M426

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tfc, PDBe:7tfc, PDBj:7tfc
• PDBsum: 7tfc
• PubMed: 35778410
• UniProt: A0A085CCI2