Structure of PDB 7oni Chain R Binding Site BS02

Receptor Information
>7oni Chain R (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVW
GECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oni Chain R Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7oni CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C61 C64 C73 C87
Binding residue
(residue number reindexed from 1)		C34 C37 C46 C60
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019788 NEDD8 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0061663 NEDD8 ligase activity
GO:0097602 cullin family protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0038026 reelin-mediated signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0045116 protein neddylation
GO:0051775 response to redox state
GO:0070979 protein K11-linked ubiquitination
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031466 Cul5-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oni, PDBe:7oni, PDBj:7oni
PDBsum7oni
PubMed34518685
UniProtQ9UBF6|RBX2_HUMAN RING-box protein 2 (Gene Name=RNF7)

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