Structure of PDB 7nhn Chain R Binding Site BS02

Receptor Information

>7nhn Chain R (length=118) Species: 169963 (Listeria monocytogenes EGD-e)

ITKIDKNKVRKKRHARVRSKISGTESRPRLNVFRSNKNIYAQIIDDVNGV
TLASASNLDKDFGSAESKVDAASKVGELVAKRASEKGITSVTFDRGGYLY
HGRVKALAEAARENGLEF

Ligand information

>7nhn Chain B (length=114)

cugguaguuauggcgagaaggucacacccguucccaucccgaacacggua
guuaagcuucucugcgccaaugguaguugggggcuucccccugcgagagu
aggucgcugccggg

<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..
>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>......
.>>>.>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nhn Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): K4 D6 K7 K9 R11 H15 R19 N32 R35 S36 N37 K38 N39 Y41 Q43 G50 V51 T52 L59 S68 V70 L100 H102 G103 R104
• Binding residue (residue number reindexed from 1): K3 D5 K6 K8 R10 H14 R18 N31 R34 S35 N36 K37 N38 Y40 Q42 G49 V50 T51 L58 S67 V69 L99 H101 G102 R103

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7nhn, PDBe:7nhn, PDBj:7nhn
• PDBsum: 7nhn
• PubMed: 34117249
• UniProt: Q8Y445|RL18_LISMO Large ribosomal subunit protein uL18 (Gene Name=rplR)