Structure of PDB 7ju4 Chain R Binding Site BS02

Receptor Information

>7ju4 Chain R (length=436) Species: 3055 (Chlamydomonas reinhardtii)

REVISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTIGGGDDAFNT
FFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAAN
NFARGHYTIGKEIVDLALDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGS
LLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVA
VMLDNEAIYDICRRSLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVD
ITEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNAAFEPASM
MVKCDPRHGKYMACCLMYRGDVVPKDVNASVATIKTKRTIQFVDWCPTGF
KCGINYQPPTVVPGGDLAKVQRAVCMISNSTAIGEIFSRLDHKFDLMYAK
RAFVHWYVGEGMEEGEFSEAREDLAALEKDFEEVGA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7ju4 Chain R Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ju4 Structures of radial spokes and associated complexes important for ciliary motility.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): E71 T145
• Binding residue (residue number reindexed from 1): E70 T144
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007010 cytoskeleton organization
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:7ju4, PDBe:7ju4, PDBj:7ju4
• PDBsum: 7ju4
• PubMed: 33318703
• UniProt: P09204|TBA1_CHLRE Tubulin alpha-1 chain (Gene Name=TUBA1)